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The most common symptom is bone pain, often in the vertebrae (bones of the spine), pelvis, or ribs.
Spread of cancer into other bones such as the femur is usually to the proximal or nearby part of the bone.
Early prostate cancer usually has no clear symptoms.
In prostate cancer, the cells of these prostate glands mutate into cancer cells.
This SNP explains part of the increased prostate cancer risk of African American men as compared to American men of European descent, since the C allele is much more prevalent in the latter; this SNP is located in the promoter region of the MSMB gene, thus affects the amount of MSMB protein synthesized and secreted by epithelial cells of the prostate.
Infection or inflammation of the prostate (prostatitis) may increase the chance for prostate cancer while another study shows infection may help prevent prostate cancer by increasing blood flow to the area.
Prostate cancer is associated with urinary dysfunction as the prostate gland surrounds the prostatic urethra.
Changes within the gland, therefore, directly affect urinary function.
Androgens are also responsible for secondary sex characteristics such as facial hair and increased muscle mass.